Origin and evolution of synaptic proteins

Morey C, Kienle CN, Klöpper TH, Burkhardt P and Fasshauer D (2017) Evidence for a conserved inhibitory binding mode between the membrane fusion assembly factors Munc18 and syntaxin in animals. JBC (292) 20449-20460.

Burkhardt P and Sprecher SG (2017) Evolutionary origin of synapses and neurons – Bridging the gap. BioEssays (39) 1700024.

Hoffmeyer TT and Burkhardt P (2016) Choanoflagellate models – Monosiga brevicollis and Salpingoeca rosetta. Curr. Opin. Gen. & Dev. (39) 42-47.

Bhattacharyya M*, Stratton MM*, Going CC*, McSpadden E, Huang Y, Susa AC, Elleman A, Cao YM, Pappireddi N, Burkhardt P, Gee C, Barros T, Schulman H, Williams ER and Kuriyan J. Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II. (2016) eLife 10.7554/eLife.13405 (*joint 1st author).

Burkhardt P (2015) The origin and evolution of synaptic proteins – choanoflagellates lead the way. (2015) J Exp Biol (218), 506-514.

Burkhardt P, Gronborg M, McDonald K, Tulur T, Wang Q and King N (2014) Evolutionary insights into premetazoan functions of the neuronal protein Homer. Mol. Biol. Evol. (31), 2342–2355.

Demircioglu FD, Burkhardt P, Fasshauer D (2014) The SM protein Sly1 accelerates assembly of the ER-Golgi SNARE complex. PNAS (111), 13828-13833.

Sebe-Pedros A*, Burkhardt P*, Sánchez-Pons N, Fairclough SR, Lang F, King N and Ruiz- Trillo I (2013) Insights into the origin of metazoan filopodia and microvilli. Mol. Biol. Evol. 30 (9): 2013-2023 (*joint 1st author).

Colbert KN, Hattendorf DA, Weiss TM, Burkhardt P, Fasshauer D and Weis WI (2013) Syntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformation. PNAS 110 (31): 12637-42.

Meijer M*, Burkhardt P*, de Wit H, Toonen RF, Fasshauer D and Verhage M (2012) Munc18-1 mutations that abolish SNARE-complex binding support normal synaptic transmission. EMBO Journal (31): 2156-2168 (*joint 1st author).

Burkhardt P, Stegmann CM, Cooper B, Kloepper TH, Imig C, Varoqueaux F, Wahl MC and Fasshauer D (2011) Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis. PNAS, 108 (37): 15264-15269.

Burkhardt P, Hattendorf DA, Weis WI, Fasshauer D (2008) Munc18 controls SNARE assembly through its interaction with the syntaxin N-peptide. EMBO Journal (27): 923-933.