An ambitious project to map the genomes of all life of the British Isles
An unprecedented insight to the diverse range of species on and around the British Isles will be made possible by Wellcome funding to the Darwin Tree of Life Project.
The £9.4m funding will support the 10 Institutions involved in the project to launch the first phase of sequencing all the species on and around the British Isles. This will see the teams collect and barcode around 8000 key British species, and deliver high-quality genomes of 2000 species.
This work will act as a launchpad for a larger ambition to, ultimately, sequence all species on Earth. Exploring the genomes of these organisms will give an unprecedented insight into how life on Earth evolved and uncover new genes, proteins and metabolic pathways as well as new drugs for infectious and inherited diseases.
And at a time when many species are under threat from climate change and human development, these data will also help characterise, catalogue and support conservation of global biodiversity for future generations.
From the small fraction of the Earth’s species that have been sequenced, enormous advances have been made in knowledge and biomedicine. Scientists at the Marine Biological Association (MBA) are using marine invertebrates to understand basic mechanisms such as tissue regeneration and neurogenesis. Through our research we hope to gain insights into these mechanisms that may have future applications such as tissue engineering and nerve regeneration. Find out more.
The consortium of 10 research institutes, museums and associated organisations ultimately aims to sequence the genetic code of 60,000 species that live in the British Isles
The 10 Institutes involved in the project are:
- University of Cambridge
- Earlham Institute (EI)
- University of Edinburgh
- EMBL’s European Bioinformatics Institute (EMBL-EBI)
- The Marine Biological Association (Plymouth)
- Natural History Museum
- Royal Botanic Gardens, Kew
- Royal Botanic Garden Edinburgh
- University of Oxford
- Wellcome Sanger Institute
Working together the centres will identify and collect specimens, set up new pipelines and workflows to process large numbers of species through DNA preparation, sequencing, assembly, gene finding and annotation. New methods will be developed for high-throughput and high-quality assembly of genomes and their annotation, and data will be shared openly through existing data sharing archives and project specific portals.
These data will be of enormous value to the international scientific community, including those working in life-sciences, medicine, alternative energy and climate research. The data will also act as a global resource for public engagement experts, naturalists, citizen scientists, university students and schools.
Professor Mark Blaxter, Lead of the Darwin Tree of Life Programme at the Wellcome Sanger Institute, said: “The Darwin Tree of Life Project will change biology forever, delivering new insights into the numerous animals, plants, fungi and protists that call the British Isles home. The impact of this work will be equivalent to the effect the Human Genome Project has had on human health over the last 25 years.”
Michael Dunn, Head of genetics and molecular sciences at Wellcome, said: “The mission to sequence all life on the British Isles is ambitious, but by bringing together this diverse group of organisations with expertise in sample collection, DNA sequencing and data processing we believe that we have the right team to achieve this. We’ll gain new insights into nature that will help develop new treatments for infectious diseases, identify drugs to slow ageing, generate new approaches to feeding the world or create new bio materials.”
Nova Mieszkowska, lead researcher for the MBA said: “The southwest is a hotspot for marine biodiversity as it is located in a transitional zone between colder and warmer waters and many species reach their biogeographic limits of distribution in this area. Therefore, the marine component of the DToL will have a southwest focus and will highlight the range of species that can be found in local coastal waters. International experts will work alongside MBA researchers to collect specimens of local species including seaweeds and animals, so that their genomes can be sequenced at the Sanger Institute, providing new information on all of the heritable traits of an organism that will revolutionise our understanding of marine life. This study is a collaboration between biodiversity, genomics and analysis partners that hopes to transform the way we do biology, conservation and biotechnology across the globe.”
The Darwin Tree of Life project is a member of, and will contribute to the aims of the Earth Biogenome Project: https://www.earthbiogenome.org/
The lead researcher for the MBA is Dr Nova Mieszkowska @MarClim_UK
The Media Manager for Wellcome is Simon Shears
For Sanger enquires contact Emily Mobley
Media Manager, Wellcome Sanger Institute
Cambridge, CB10 1SA
Phone: 01223 496851
The Wellcome Sanger Institute
The Wellcome Sanger Institute is a world leading genomics research centre. We undertake large-scale research that forms the foundations of knowledge in biology and medicine. We are open and collaborative; our data, results, tools and technologies are shared across the globe to advance science. Our ambition is vast – we take on projects that are not possible anywhere else. We use the power of genome sequencing to understand and harness the information in DNA. Funded by Wellcome, we have the freedom and support to push the boundaries of genomics. Our findings are used to improve health and to understand life on Earth. Find out more at www.sanger.ac.uk or follow us on Twitter, Facebook, LinkedIn and on our Blog.
Wellcome exists to improve health by helping great ideas to thrive. We support researchers, we take on big health challenges, we campaign for better science, and we help everyone get involved with science and health research. We are a politically and financially independent foundation.
European Bioinformatics Institute (EMBL-EBI)
The European Bioinformatics Institute (EMBL-EBI) is a global leader in the storage, analysis and dissemination of large biological datasets. We help scientists realise the potential of ‘big data’ by enhancing their ability to exploit complex information to make discoveries that benefit humankind.
We are at the forefront of computational biology research, with work spanning sequence analysis methods, multi-dimensional statistical analysis and data-driven biological discovery, from plant biology to mammalian development and disease.
We are part of EMBL and are located on the Wellcome Genome Campus, one of the world’s largest concentrations of scientific and technical expertise in genomics.